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KMID : 0358819880150030443
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1988 Volume.15 No. 3 p.443 ~ p.447
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EXPERIMENTAL STUDY OF PHARMACOLOGIC AGENTS TO INCREASE THE FLAP SURVIVAL WITH PENTOXYLLINE,
CHLOROPROMAZINE AND PREDNISOLONE
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김덕래/Kim, Duck Lae
전건수/구상환/정전은/Chun, Kun Soo/Koo, Sang Hwon/Chung, Chun Eun
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Abstract
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There are several kinds of known pharmacological agents to increase the flap survival. Those are known to be sympatholytics, vasdilators, rheologic agents and drugs which increase the tolerance of ischemia. Even though, many experimental studies were reported, however, the results were conflicting. Therefore, we select three medicines which are more known to be effective for flap survival. Those are Pentoxylline (Trental), Chloropromazine (Sepamine) and Prednisolone.
Experimental study was performed on rats to demonstrate the efficacy of them. We used 40 Sprague-Dawley rats which were divided into 4 groups; those were treated with Pentoxyfylline, with Chloropromazine, with Prednisolone and with saline as a control. Cranially based McFarlane flaps were used in the midline of the dorsums of rats. The surviving lengths were measured From this experiment, we proved that those three medicines are very effective and almost samely effective to increase the flap survival.
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KEYWORD
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